The Office has six main functions:

The staff are committed to ensuring that the Office's facilities are made available to a broad range of interests including the non-government, local government, academic and private sectors. Many Nothern Ireland-based organisations have used the facilities to hold meetings and events. The activities of the Office also assist in promoting knowledge and understanding of the European Union in Northern Ireland and staff have developed a strong relationship with the European Commission representation in Belfast.

As part of the development of inter-regional co-operation with the other European regions, the Northern Ireland administration has joined the Conference of Peripheral Maritime Regions (CPMR). This organisation brings together representatives of most regions outside central Europe to discuss issues of mutual interest.